SPINA (structure parameter inference approach) is a method for calculating constant structure parameters of endocrine feedback control systems in vivo from hormone levels obtained from serum or plasma.
A first successful implementation applies to evaluation of thyroid function. It allows for calculating the thyroid's maximum secretory capacity (GT or SPINA-GT) and the sum activity of peripheral 5'-deiodinases (GD or SPINA-GD) from levels of TSH, (F)T4 and (F)T3 that have been determined once only (SPINA Thyr).
SimThyr is a simulation program for thyroid homeostasis. It is based on a published nonlinear parametric isomorphic model of thyrotropic feedback control. Applications of SimThyr cover generation of hypotheses for biomedical research, education and presentation. Binaries and sourcecode are available for Mac OS, Mac OS X, Windows, Linux and other Unix derivatives.
In the last 20 years, researchers have investigated solutions to enable seamless access to online resources within the context of electronic health record (EHR) systems. “Infobuttons” are among these solutions. Based on contextual attributes that describe the EHR user, the patient, and the care setting, infobuttons anticipate clinicians’ information needs and provide automated links to a set of relevant knowledge resources to assist clinical decision support.
MRIdb is an end-to-end data management system for MRI, combining the DCM4CHEE DICOM server with a bespoke front-end packaged into an easily deployable virtual machine. It interfaces directly with MRI scanners and handles image storage, retrieval and export. It provides role-based access control, patient-study assignment, and extensive auditing. MRIdb is the result of an ongoing collaboration between the BSS and the Imaging Sciences Department of Imperial College.
CollaboRhythm is a technology platform that enables a new paradigm of healthcare delivery; one where patients are empowered to become active participants and where doctors and other health professionals are transformed into real-time coaches. We believe that this radical shift in thinking is necessary to dramatically reduce healthcare costs, increase quality, and improve health outcomes.
ADDIS is a software developed within the Dutch Escher-project for managing and analyzing clinical trial information.
ADDIS is a proof-of-concept system that allows us to simultaneously discover the possibilities of and the requirements on a database of structured clinical trials data. The automated discovery and (meta-)analysis of trial data, as well as benefit-risk assessment is supported.
The Arden Syntax as a standardized language to represent medical knowledge can be used to express medical knowledge.
Arden2ByteCode is a newly developed open source compiler for the Arden Syntax. Arden2ByteCode runs on Java Virtual Machines (JVM) and translates Arden Syntax directly to Java bytecode (JBC)
executable on JVMs.
It also serves as runtime environment for execution of the compiled bytecode.
The complexity of cellular networks is an outstanding challenge for documentation, visualisation and mathematical modelling. In this project, we develop a new way to describe these networks that minimises the combinatorial complexity and allows an automatic visualisation and export of mathematical (ODE/rulebased) models.
Automatic visualiztion with Cytoscape.
Automatic generation of rule based models for BioNetGen.
Storage of biological facts that can be used for modelling.