@article {917,
	title = {TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis.},
	journal = {J Thyroid Res},
	volume = {2012},
	year = {2012},
	month = {2012},
	pages = {351864},
	abstract = {<p>This paper provides the reader with an overview of our current knowledge of hypothalamic-pituitary-thyroid feedback from a cybernetic standpoint. Over the past decades we have gained a plethora of information from biochemical, clinical, and epidemiological investigation, especially on the role of TSH and other thyrotropic agonists as critical components of this complex relationship. Integrating these data into a systems perspective delivers new insights into static and dynamic behaviour of thyroid homeostasis. Explicit usage of this information with mathematical methods promises to deliver a better understanding of thyrotropic feedback control and new options for personalised diagnosis of thyroid dysfunction and targeted therapy, also by permitting a new perspective on the conundrum of the TSH reference range.</p>},
	issn = {2042-0072},
	doi = {10.1155/2012/351864},
	author = {Dietrich, Johannes W and Landgrafe, Gabi and Fotiadou, Elisavet H}
}
