%0 Journal Article %J PLoS ONE %D 2010 %T JULIDE: A Software Tool for 3D Reconstruction and Statistical Analysis of Autoradiographic Mouse Brain Sections %A Ribes, Delphine %A Parafita, Julia %A Charrier, Rémi %A Magara, Fulvio %A Magistretti, Pierre J. %A Thiran, Jean-Philippe %X

In this article we introduce JULIDE, a software toolkit developed to perform the 3D reconstruction, intensity normalization, volume standardization by 3D image registration and voxel-wise statistical analysis of autoradiographs of mouse brain sections. This software tool has been developed in the open-source ITK software framework and is freely available under a GPL license. The article presents the complete image processing chain from raw data acquisition to 3D statistical group analysis. Results of the group comparison in the context of a study on spatial learning are shown as an illustration of the data that can be obtained with this tool.

%B PLoS ONE %I Public Library of Science %V 5 %P e14094 %8 11 %U http://dx.doi.org/10.1371%2Fjournal.pone.0014094 %R 10.1371/journal.pone.0014094 %0 Journal Article %J PLoS One %D 2010 %T JULIDE: a software tool for 3D reconstruction and statistical analysis of autoradiographic mouse brain sections. %A Ribes, Delphine %A Parafita, Julia %A Charrier, Rémi %A Magara, Fulvio %A Magistretti, Pierre J %A Thiran, Jean-Philippe %K Animals %K Autoradiography %K Brain %K Carbon Radioisotopes %K Deoxyglucose %K Image Processing, Computer-Assisted %K Imaging, Three-Dimensional %K Male %K Maze Learning %K Mice %K Mice, Inbred C57BL %K Reproducibility of Results %K Software %X

In this article we introduce JULIDE, a software toolkit developed to perform the 3D reconstruction, intensity normalization, volume standardization by 3D image registration and voxel-wise statistical analysis of autoradiographs of mouse brain sections. This software tool has been developed in the open-source ITK software framework and is freely available under a GPL license. The article presents the complete image processing chain from raw data acquisition to 3D statistical group analysis. Results of the group comparison in the context of a study on spatial learning are shown as an illustration of the data that can be obtained with this tool.

%B PLoS One %V 5 %P e14094 %8 2010 %G eng %N 11 %R 10.1371/journal.pone.0014094