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JULIDE: a software tool for 3D reconstruction and statistical analysis of autoradiographic mouse brain sections.

Submitted by karopka on Fri, 2015/10/23 - 15:32
TitleJULIDE: a software tool for 3D reconstruction and statistical analysis of autoradiographic mouse brain sections.
Publication TypeJournal Article
Year of Publication2010
AuthorsRibes, D, Parafita, J, Charrier, R, Magara, F, Magistretti, PJ, Thiran, J-P
JournalPLoS One
Volume5
Issue11
Paginatione14094
Date Published2010
ISSN1932-6203
KeywordsAnimals, Autoradiography, Brain, Carbon Radioisotopes, Deoxyglucose, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Male, Maze Learning, Mice, Mice, Inbred C57BL, Reproducibility of Results, Software
Abstract

In this article we introduce JULIDE, a software toolkit developed to perform the 3D reconstruction, intensity normalization, volume standardization by 3D image registration and voxel-wise statistical analysis of autoradiographs of mouse brain sections. This software tool has been developed in the open-source ITK software framework and is freely available under a GPL license. The article presents the complete image processing chain from raw data acquisition to 3D statistical group analysis. Results of the group comparison in the context of a study on spatial learning are shown as an illustration of the data that can be obtained with this tool.

DOI10.1371/journal.pone.0014094
Alternate JournalPLoS ONE
PubMed ID21124830
PubMed Central IDPMC2991313
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