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Integrating Heterogeneous Biomedical Data for Cancer Research: the CARPEM infrastructure.

Submitted by karopka on Wed, 2016/08/10 - 14:53
TitleIntegrating Heterogeneous Biomedical Data for Cancer Research: the CARPEM infrastructure.
Publication TypeJournal Article
Year of Publication2016
AuthorsRance, B, Canuel, V, Countouris, H, Laurent-Puig, P, Burgun, A
JournalAppl Clin Inform
Date Published2016

Cancer research involves numerous disciplines. The multiplicity of data sources and their heterogeneous nature render the integration and the exploration of the data more and more complex. Translational research platforms are a promising way to assist scientists in these tasks. In this article, we identify a set of scientific and technical principles needed to build a translational research platform compatible with ethical requirements, data protection and data-integration problems. We describe the solution adopted by the CARPEM cancer research program to design and deploy a platform able to integrate retrospective, prospective, and day-to-day care data. We designed a three-layer architecture composed of a data collection layer, a data integration layer and a data access layer. We leverage a set of open-source resources including i2b2 and tranSMART.

Alternate JournalAppl Clin Inform
PubMed ID27437039
PubMed Central IDPMC4941838
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