|Title||TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Dietrich, JW, Landgrafe, G, Fotiadou, EH|
|Journal||J Thyroid Res|
This paper provides the reader with an overview of our current knowledge of hypothalamic-pituitary-thyroid feedback from a cybernetic standpoint. Over the past decades we have gained a plethora of information from biochemical, clinical, and epidemiological investigation, especially on the role of TSH and other thyrotropic agonists as critical components of this complex relationship. Integrating these data into a systems perspective delivers new insights into static and dynamic behaviour of thyroid homeostasis. Explicit usage of this information with mathematical methods promises to deliver a better understanding of thyrotropic feedback control and new options for personalised diagnosis of thyroid dysfunction and targeted therapy, also by permitting a new perspective on the conundrum of the TSH reference range.
|Alternate Journal||J Thyroid Res|
|PubMed Central ID||PMC3544290|