You are here

TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis.

Submitted by holger on Tue, 2013/12/17 - 08:33
TitleTSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis.
Publication TypeJournal Article
Year of Publication2012
AuthorsDietrich, JW, Landgrafe, G, Fotiadou, EH
JournalJ Thyroid Res
Date Published2012

This paper provides the reader with an overview of our current knowledge of hypothalamic-pituitary-thyroid feedback from a cybernetic standpoint. Over the past decades we have gained a plethora of information from biochemical, clinical, and epidemiological investigation, especially on the role of TSH and other thyrotropic agonists as critical components of this complex relationship. Integrating these data into a systems perspective delivers new insights into static and dynamic behaviour of thyroid homeostasis. Explicit usage of this information with mathematical methods promises to deliver a better understanding of thyrotropic feedback control and new options for personalised diagnosis of thyroid dysfunction and targeted therapy, also by permitting a new perspective on the conundrum of the TSH reference range.

Alternate JournalJ Thyroid Res
PubMed ID23365787
PubMed Central IDPMC3544290
Your rating: None Average: 5 (7 votes)
Related project(s): 
Related organization or other resource: