SimThyr is a simulation program for thyroid homeostasis. It is based on a published nonlinear parametric isomorphic model of thyrotropic feedback control. Applications of SimThyr cover generation of hypotheses for biomedical research, education and presentation. Binaries and sourcecode are available for Mac OS, Mac OS X, Windows, Linux and other Unix derivatives.
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SPINA (structure parameter inference approach) is a method for calculating constant structure parameters of endocrine feedback control systems in vivo from hormone levels obtained from serum or plasma.
A first successful implementation applies to evaluation of thyroid function. It allows for calculating the thyroid's maximum secretory capacity (GT or SPINA-GT) and the sum activity of peripheral 5'-deiodinases (GD or SPINA-GD) from levels of TSH, (F)T4 and (F)T3 that have been determined once only (SPINA Thyr).
CyberUnits is a cross-platform class library for rapid programming of high-performance computer simulations in life sciences. It supports modelling for biomedical cybernetics and systems biology with Object Pascal, S and Matlab.
Mirth is an open source cross-platform HL7 interface engine that enables bi-directional sending of HL7 messages between systems and applications over multiple transports. It is divided in three subprojects:
- Mirth Connect: Specifically designed for HL7 message integration, Mirth Connect provides the necessary tools for developing, testing, deploying, and monitoring interfaces.
The DHIS 2 is a tool for collection, validation, analysis, and presentation of aggregate statistical data, tailored (but not limited) to integrated health information management activities. It is a generic tool rather than a pre-configured database application, with an open meta-data model and a flexible user interface that allows the user to design the contents of a specific information system without the need for programming. DHIS 2 and upwards is a modular web-based software package built with free and open source Java frameworks.